在线客服1号
抗小鼠 CD4 单克隆抗体 PE-Cyanine7 偶联，流动验证 BES2309LAb
| 货号 | BES2309LAb |
|---|---|
| 产品名称 | 抗小鼠 CD4 单克隆抗体 PE-Cyanine7 偶联，流动验证 |
| 基因名 | CD4 |
| 抗体来源 | Rat |
| 克隆 | Monoclonal |
| 抗体亚型 | Rat |
| 内容 | Phosphate-buffered aqueous solution, 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2. |
| 浓度 | 500 ug/ml |
| 产品形态 | Liquid |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing. |
| 背景资料 | This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
| 研究类别 | 1. Ansari-Lari, M. A., Muzny, D. M., Lu, J., Lu, F., Lilley, C. E., Spanos, S., Malley, T., Gibbs, R. A. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 6: 314-326, 1996.2. Ben-Sasson, S. Z., Hu-Li, J., Quiel, J., Cauchetaux, S., Ratner, M., Shapira, I., Dinarello, C. A., Paul, W. E. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Nat. Acad. Sci. 106: 7119-7124, 2009.3. Buttini, M., Westland, C. E., Masliah, E., Yafeh, A. M., Wyss-Coray, T., Mucke, L. Novel role of human CD4 molecule identified in neurodegeneration. Nature Med. 4: 441-446, 1998. |